Tweak (?), v. t. [OE. twikken, originally the same word as twicchen; cf. LG. twikken. See Twitch.] To pinch and pull with a sudden jerk and twist; to twitch; as, to tweak the nose. Shak.

Tweak, n. 1. A sharp pinch or jerk; a twist or twitch; as, a tweak of the nose. Swift.

2. Trouble; distress; tweag. [Obs.]

3. A prostitute. [Obs.] Brathwait.

Tweak (?), v. t. [OE. twikken, originally the same word as twicchen; cf. LG. twikken. See Twitch.] To pinch and pull with a sudden jerk and twist; to twitch; as, to tweak the nose. Shak.

Tweak, n. 1. A sharp pinch or jerk; a twist or twitch; as, a tweak of the nose. Swift.

2. Trouble; distress; tweag. [Obs.]

3. A prostitute. [Obs.] Brathwait.

• A sharp pinch or jerk; a twist or twitch; as, a tweak of the nose.
  
• trouble; distress; tweag.
  
• A slight adjustment or modification.
       He is running so many tweaks it is hard to remember how it looked originally.
  
• A prostitute.
  
• (transitive): To pinch and pull with a sudden jerk and twist; to twitch; as, to tweak the nose.
  
• (transitive), (slang) To adjust slightly; to fine tune.
       If we tweak the colors towards blue, it will look more natural.
  
• (transitive): To twit or tease.
  
• (slang), (US), (intransitive): To abuse methamphetamines, especially crystal meth.